Patten, GabrielaMalateste, KarenBolton-Moore, CarolynSipambo, NosisaMokone, LimphoAnderegg, NaninaWools-Kaloustian, KaraMichael, DennaOdhiambo, FrancescaKasozi, CharlesDesmonde, SophieAmorissani-Folquet, MadeleineLeroy, ValérianeKumara, Dewi W.Nallusamy, RevathyKinikar, AartiQuy, Du T.Yotebieng, MarcelEbasone, Peter V.Lelo, PatriciaPinto, JorgeRouzier, VanessaMachado, Daisy M.Haw, Nel J.Ford, Nathan2025-09-172025-Apr-010.1097/INF.0000000000004819https://pubs.cidrz.org/handle/123456789/12071Eligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.https://pubmed.ncbi.nlm.nih.gov/40233289/