Browsing by Author "Ayles, Helen M."

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    Final Analysis of a Trial of M72/AS01
    (2019-Dec-19) Tait, Dereck R.; Hatherill, Mark; Van Der Meeren, Olivier; Ginsberg, Ann M.; Van Brakel, Elana; Salaun, Bruno; Scriba, Thomas J.; Akite, Elaine J.; Ayles, Helen M.; Bollaerts, Anne; Demoitié, Marie-Ange ; Diacon, Andreas; Evans, Thomas G.; Gillard, Paul; Hellström, Elizabeth ; Innes, James C.; Lempicki, Maria; Malahleha, Mookho; Martinson, Neil; Mesia, Doris V.; Muyoyeta, Monde; Nduba, Videlis; Pascal, Thierry G.; Tameris, Michele ; Thienemann, Friedrich ; Wilkinson, Robert J.; Roman, François
    BACKGROUND: Results of an earlier analysis of a trial of the M72/AS01 METHODS: From August 2014 through November 2015, we enrolled adults 18 to 50 years of age with RESULTS: A total of 3575 participants underwent randomization, of whom 3573 received at least one dose of M72/AS01 CONCLUSIONS: Among adults infected with
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    Phase 2b Controlled Trial of M72/AS01
    (2018-Oct-25) Van Der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German ; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitié, Marie-Ange ; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellström, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Azam, Aisha K.; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R.
    BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01 RESULTS: We report the primary analysis (conducted after a mean of 2.3 years of follow-up) of the ongoing trial. A total of 1786 participants received M72/AS01 CONCLUSIONS: M72/AS01