Browsing by Author "Beck IA"

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    Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.
    (2020-Apr-30) Higa N; Pelz A; Birch D; Beck IA; Sils T; Samson P; Bwakura-Dangarembizi M; Bolton-Moore C; Capparelli E; Chadwick E; Frenkel LM; University of California, San Diego, La Jolla.; University of Alabama at Birmingham, Alabama.; Centre for Infectious Disease Research in Zambia, Lusaka.; University of Washington, Seattle.; University of Zimbabwe College of Health Sciences, Harare.; Seattle Children's Research Institute, Washington.; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.; Northwestern University Feinberg School of Medicine, Chicago, Illinois.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
    Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.