Browsing by Author "Buzaalirwa, Lydia"

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    Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study.
    (2025-May-20) Loosli, Tom; Bolton-Moore, Carolyn; Buzaalirwa, Lydia; Byakwaga, Helen; Çelikağ, İpek; Chimbetete, Cleophas; Ebasone, Peter V.; Giandhari, Jennifer; Han, Nuri; Huwa, Jacqueline; Kasozi, Charles; Mafoua, Adolphe; Messou, Eugène ; Minga, Albert; Muula, Guy; Muyindike, Winnie; Ndala, Arcel C. M.; Sauermann, Mamatha ; Semeere, Aggrey; Singh, Lavanya; Kouyos, Roger D.; Lessells, Richard; Egger, Matthias
    Dolutegravir resistance is an increasing concern. An analysis of the DTG RESIST study found that among 227 integrase sequences from 7 African countries (all non-B subtypes), 59 (26.0%) had at least 1 major drug resistance mutation (primarily G118R and E138A/K/T), with 49 (21.6%) predicted to have high-level resistance to dolutegravir.