Browsing by Author "Johnston R"

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    Gender equality and quality of life must be central to the design and delivery of sanitation.
    (2025-Jan-22) Marphatia AA; Simiyu S; Flint O'Kane M; Alexander KT; Nascimento de Castro ACA; Azcona G; Boni-Morkla PE; Bukachi SA; Busienei P; Caruso BA; Chase C; Chipungu J; Dwivedi A; Johnston R; Khurana I; Kome A; Kuria W; Labadia J; Makoni F; Mberu B; Mojumdar S; Mule J; Namatende Sakwa L; Njeri N; Oliveira de Souza FA; Pandolfelli L; Ramunenyiwa P; Ray I; Reddy M; Saha PK; Sinha U; Sinharoy SS; Slaymaker T; Uguru E; Uhl K; Young SL; Ross I; Cumming O; Department of Environment, Climate Change and Health, World Health Organization, Geneva, Switzerland.; World Vision Kenya, Nairobi, Kenya.; African Population and Health Research Center, Nairobi, Kenya.; Parmarth Samaj Sevi Sansthan, Jalaun, India.; Energy and Resources Group, UC Berkeley, Berkeley, California, USA.; African Ministers Council on Water, Abuja, Nigeria.; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.; Department of Water and Sanitation, Government of South Africa, Pretoria, South Africa.; Research and Data Section, UN Women, New York, New York, USA.; Department of Anthropology, Gender and African Studies, University of Nairobi, Nairobi, Kenya.; Tarun Bharat Sangh, Bheekampura - Kishori, India.; Water Sanitation and Hygiene Team, UNICEF India, New Delhi, India.; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK akanksha.marphatia@lshtm.ac.uk.; Centre for Policy Research, New Delhi, India.; SNV, Netherlands, The Hague, Netherlands.; Ministry of Sanitation and Water Resources, Government of Ghana, Accra, Ghana.; Water and Sanitation for the Urban Poor, Dhaka, Bangladesh.; Center for Infectious Disease Research in Zambia, Lusaka, Zambia.; School of Public Policy and Global Affairs, University of British Columbia, Vancouver, BC, Canada.; Division of Data, Analytics, Planning and Monitoring, UNICEF, New York, New York, USA.; CARE, Atlanta, Georgia, USA.; Re Sustainability Limited, Hyderabad, India.; Bill and Melinda Gates Foundation, Seattle, Washington, USA.; National Basic Water and Sanitation Agency, Federal Government of Brazil, Brasilia, Brazil.; Water Global Practice, World Bank Group, Washington, DC, USA.; Department of Environmental Health and Sanitation, Government of Kenya, Nairobi, Kenya.; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.; CARE South Sudan, Juba, Sudan.; Department of Anthropology, Northwestern University, Evanston, Illinois, USA.; Great Ormond Street Institute of Child Health, UCL, London, UK.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
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    Multi-stakeholder consensus on a target product profile for an HIV cure.
    (2021-Jan) Lewin SR; Attoye T; Bansbach C; Doehle B; Dubé K; Dybul M; SenGupta D; Jiang A; Johnston R; Lamplough R; McCune JM; Nabel GJ; Ndung'u T; Pottage J; Ripin D; Rooney JF; Sikazwe I; Nsubuga M; Warren M; Deeks SG; Sanofi Global Research and Development, Cambridge, MA, USA.; University of California, San Francisco, CA, USA.; International AIDS Society, Geneva, Switzerland.; Bill & Melinda Gates Foundation, Seattle, WA, USA.; HIV Frontiers, Global Health Innovative Technology Solutions, The Bill & Melinda Gates Foundation, Seattle, WA, USA.; The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia; Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, VIC, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC, Australia. Electronic address: sharon.lewin@unimelb.edu.au.; Joint Adherent Brothers & Sisters against AIDS, Kampala, Uganda.; Gilead Sciences, Foster City, CA, USA.; McKinsey & Company Secondee at The Bill & Melinda Gates Foundation, Seattle, WA, USA.; AVAC, New York, NY, USA.; amfAR, The Foundation for AIDS Research, New York City, NY, USA.; Center for Global Health Practice and Impact, Georgetown University, Washington, DC, USA.; Africa Health Research Institute, Durban, South Africa; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Division of Infection and Immunity, University College London, London, UK.; ViiV Healthcare, Brentford, UK.; Clinton Health Access Initiative, Boston, MA, USA.; Department of Global Health, University of Washington, The Bill & Melinda Gates Foundation, Seattle, WA, USA.; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.; University North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
    Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures.