Browsing by Author "Naqvi F"

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    Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries.
    (2023-May-23) Manasyan A; Salas AA; Nolen T; Chomba E; Mazariegos M; Tshefu Kitoto A; Saleem S; Naqvi F; Hambidge KM; Goco N; McClure EM; Wallander JL; Biasini FJ; Goldenberg RL; Bose CL; Koso-Thomas M; Krebs NF; Carlo WA; University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.; Aga Khan University, Karachi, Pakistan.; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.; Research Triangle Institute, Durham, North Carolina, USA.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.; Department of Pediatrics, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA AlbertManasyan@uabmc.edu.; Department of Obstetrics and Gynecology, Columbia University, New York, New York, UK.; University of Kinshasa, Kinshasa, Congo (the Democratic Republic of the).; Psychological Sciences and Health Sciences Research Institute, University of California Merced, Merced, California, USA.; University of Colorado Denver, Denver, Colorado, USA.; University of Zambia, Lusaka, Zambia.; Department of Reproductive, Maternal, Newborn, and Child Health, Center for Infectious Disease Research in Zambia, Lusaka, Zambia.; Institute of Nutrition for Central America and Panamá (INCAP), Guatemala City, Panama.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
    OBJECTIVE: The Bayley Scales of Infant Development (BSID) is the most used diagnostic tool to identify neurodevelopmental disorders in children under age 3 but is challenging to use in low-resource countries. The Ages and Stages Questionnaire (ASQ) is an easy-to-use, low-cost clinical tool completed by parents/caregivers that screens children for developmental delay. The objective was to determine the performance of ASQ as a screening tool for neurodevelopmental impairment when compared with BSID second edition (BSID-II) for the diagnosis of moderate-to-severe neurodevelopmental impairment among infants at 12 and 18 months of age in low-resource countries. METHODS: Study participants were recruited as part of the First Bites Complementary Feeding trial from the Democratic Republic of Congo, Zambia, Guatemala and Pakistan between October 2008 and January 2011. Study participants underwent neurodevelopmental assessment by trained personnel using the ASQ and BSID-II at 12 and 18 months of age. RESULTS: Data on both ASQ and BSID-II assessments of 1034 infants were analysed. Four of five ASQ domains had specificities greater than 90% for severe neurodevelopmental delay at 18 months of age. Sensitivities ranged from 23% to 62%. The correlations between ASQ communications subscale and BSID-II Mental Development Index (MDI) (r=0.38) and between ASQ gross motor subscale and BSID-II Psychomotor Development Index (PDI) (r=0.33) were the strongest correlations found. CONCLUSION: At 18 months, ASQ had high specificity but moderate-to-low sensitivity for BSID-II MDI and/or PDI <70. ASQ, when administered by trained healthcare workers, may be a useful screening tool to detect severe disability in infants from rural low-income to middle-income settings. TRIAL REGISTRATION NUMBER: NCT01084109.