Browsing by Author "Newton R"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Hepatitis B virus infection as a neglected tropical disease.
    (2017-Oct) O'Hara GA; McNaughton AL; Maponga T; Jooste P; Ocama P; Chilengi R; Mokaya J; Liyayi MI; Wachira T; Gikungi DM; Burbridge L; O'Donnell D; Akiror CS; Sloan D; Torimiro J; Yindom LM; Walton R; Andersson M; Marsh K; Newton R; Matthews PC; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trusts, John Radcliffe Hospital, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Chantal Biya International Reference Centre for Research on HIV/AIDS, Yaounde, Cameroon.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Division of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg, Cape Town, South Africa.; Medical-Surgical Department, Machakos Level 5 Hospital, Machakos, Kenya.; Africa-Oxford (AfOx) Initiative, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom.; Warwick Medical School, University of Warwick, Coventry, United Kingdom.; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom.; Health System Research Ethics Department, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Health Sciences, University of York, York, United Kingdom.; School of Medicine, Medical & Biological Sciences, University of St Andrews, St Andrews, Scotland, United Kingdom.; Garissa County Referral Hospital, Garissa, Kenya.; Co-infection Studies Programme, MRC/UVRI Uganda Research Unit, Entebbe, Uganda.; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.; Global Healthcare Public Foundation, Kampala, Uganda.; Patient and Public Involvement Committee, Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.; Mother and Child Health Department, Baringo County Referral Hospital, Baringo, Kenya.; Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa.; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
  • Thumbnail Image
    Item
    Kangaroo mother care for the prevention of neonatal hypothermia: a randomised controlled trial in term neonates.
    (2018-May) Ramani M; Choe EA; Major M; Newton R; Mwenechanya M; Travers CP; Chomba E; Ambalavanan N; Carlo WA; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.; Department of Pediatrics, University Teaching Hospital, Lusaka, Zambia.; CIDRZ; Centre for Infectious Disease Research in Zambia (CIDRZ)
    OBJECTIVE: To test the hypothesis that kangaroo mother care (KMC) initiated either at birth or at 1 hour after birth reduces moderate or severe hypothermia in term neonates at (A) 1 hour after birth and (B) at discharge when compared with standard thermoregulation care. METHODS: Term neonates born at a tertiary delivery centre in Zambia were randomised in two phases (phase 1: birth to 1 hour, phase 2: 1 hour to discharge) to either as much KMC as possible in combination with standard thermoregulation care (KMC group) or to standard thermoregulation care (control group). The primary outcomes were moderate or severe hypothermia (axillary temperature <36.0°C) at (A) 1 hour after birth and (B) at discharge. RESULTS: The proportion of neonates with moderate or severe hypothermia did not differ between the KMC and control groups at 1 hour after birth (25% vs 27%, relative risk (RR)=0.93, 95% CI 0.59 to 1.4, P=0.78) or at discharge (7% vs 2%, RR=2.8, 95% CI 0.6 to 13.9, P=0.16). Hypothermia was not found among the infants who had KMC for at least 9 hours or 80% of the hospital stay. CONCLUSIONS: KMC practised as much as possible in combination with standard thermoregulation care initiated either at birth or at 1 hour after birth did not reduce moderate or severe hypothermia in term infants compared with standard thermoregulation care. The current study also shows that duration of KMC either for at least 80% of the time or at least 9 hours during the day of birth was effective in preventing hypothermia in term infants. CLINICAL TRIAL REGISTRATION: NCT02189759.