Browsing by Author "Tompkins KM"

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    Diagnosis of Concurrent Pulmonary Tuberculosis and Tuberculous Otitis Media Confirmed by Xpert MTB/RIF in the United States.
    (2016-May) Tompkins KM; Reimers MA; White BL; Herce ME; University of North Carolina at Chapel Hill, Department of Internal Medicine.; The University of North Carolina at Chapel Hill School of Medicine.; University of North Carolina at Chapel Hill School of Medicine, Department of Medicine, Division of infectious diseases; Centre for Infectious Disease Research in Zambia (CIDRZ).; University of North Carolina at Chapel Hill School of Medicine, Department of Medicine, Division of infectious diseases.
    Tuberculosis (TB) remains an important cause of infectious morbidity in the United States (US), necessitating timely and accurate diagnosis. We report a case of concurrent pulmonary and extrapulmonary TB presenting as tuberculous otitis media in a hospitalized US patient admitted with cough, night sweats, and unilateral purulent otorrhea. Diagnosis was made by smear microscopy and rapidly confirmed by Xpert MTB/RIF-a novel, automated nucleic acid amplification test for the rapid detection of drug-susceptible and drug-resistant TB. This case adds to the growing body of evidence validating Xpert MTB/RIF as an effective tool for the rapid diagnosis of extrapulmonary TB, even in low TB-prevalence settings such as the US, when testing is performed on non-respiratory specimens.