Predictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia.

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dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka, Zambia. cherry.liu@cidrz.org
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorLiu KC
dc.contributor.authorMulindwa J
dc.contributor.authorGiganti MJ
dc.contributor.authorPutta NB
dc.contributor.authorChintu N
dc.contributor.authorChi BH
dc.contributor.authorStringer JS
dc.contributor.authorStringer EM
dc.date.accessioned2025-05-23T11:42:41Z
dc.date.issued2011-Aug-15
dc.description.abstractBACKGROUND: In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy. METHODS: We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women. RESULTS: The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2). CONCLUSION: CD4 triage remains a critical element of maternal HIV care and PMTCT.
dc.identifier.doi10.1097/QAI.0b013e31821d3507
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10712
dc.sourceJournal of acquired immune deficiency syndromes (1999)
dc.titlePredictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia.

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