Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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dc.contributor.affiliationMasaka Regional Referral Hospital, Masaka City, Uganda.
dc.contributor.affiliationPediatric Department, Cocody University Hospital, Abidjan, Cote d'Ivoire.
dc.contributor.affiliationChildren's Hospital 1, Ho Chi Minh City, Vietnam.
dc.contributor.affiliationCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
dc.contributor.affiliationDepartment of Pediatrics, BJ Government Medical College and Sassoon General Hospital, Pune, India.
dc.contributor.affiliationClinical Research Education, Networking and Consultancy (CRENC), Yaoundé, Cameroon.
dc.contributor.affiliationSolidarMed, Maseru, Lesotho.
dc.contributor.affiliationDepartment of Pediatrics, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Udayana University, Bali, Indonesia.
dc.contributor.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.contributor.affiliationDepartment of Paediatrics and Child Health, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa.
dc.contributor.affiliationDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
dc.contributor.affiliationUniversity of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.
dc.contributor.affiliationWorld Health Organization, Geneva, Switzerland.
dc.contributor.affiliationDepartment of Pediatrics, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.
dc.contributor.affiliationTanzanian National Institute of Medical Research, Mwanza, Tanzania.
dc.contributor.affiliationFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
dc.contributor.affiliationCentres GHESKIO, Port-au-Prince, Haiti.
dc.contributor.affiliationSchool of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
dc.contributor.affiliationKalembe Lembe Pediatric Hospital, Kinshasa, Democratic Republic of the Congo.
dc.contributor.affiliationDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
dc.contributor.affiliationCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
dc.contributor.affiliationDepartment of Pediatrics, Penang Hospital, Penang, Malaysia.
dc.contributor.affiliationDepartment of Medicine, Indiana University School of Medicine; Indianapolis, Indiana.
dc.contributor.authorPatten G
dc.contributor.authorMalateste K
dc.contributor.authorBolton Moore C
dc.contributor.authorSipambo N
dc.contributor.authorMokone L
dc.contributor.authorAnderegg N
dc.contributor.authorWools-Kaloustian K
dc.contributor.authorMichael D
dc.contributor.authorOdhiambo F
dc.contributor.authorKasozi C
dc.contributor.authorDesmonde S
dc.contributor.authorAmorissani-Folquet M
dc.contributor.authorLeroy V
dc.contributor.authorKumara Wati D
dc.contributor.authorNallusamy R
dc.contributor.authorKinikar A
dc.contributor.authorQuy DT
dc.contributor.authorYotebieng M
dc.contributor.authorEbasone PV
dc.contributor.authorLelo P
dc.contributor.authorPinto J
dc.contributor.authorRouzier V
dc.contributor.authorMachado DM
dc.contributor.authorHaw NJ
dc.contributor.authorFord N
dc.date.accessioned2025-07-10T11:06:38Z
dc.date.issued2025-Apr-04
dc.description.abstractEligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
dc.identifier.doi10.1097/INF.0000000000004819
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10907
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/40233289/
dc.sourceThe Pediatric infectious disease journal
dc.titleGlobal Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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