Point-of-Care Urine Ethyl Glucuronide Testing to Detect Alcohol Use Among HIV-Hepatitis B Virus Coinfected Adults in Zambia.

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dc.contributor.affiliationDepartment of Medicine, University of Alabama at Birmingham, Birmingham, USA. mjv3@uab.edu.
dc.contributor.affiliationDepartment of Medicine, Johns Hopkins University, Baltimore, USA.
dc.contributor.affiliationSchool of Medicine, University of Zambia, Lusaka, Zambia. mjv3@uab.edu.
dc.contributor.affiliationDepartment of Medicine, University of Alabama at Birmingham, Birmingham, USA.
dc.contributor.affiliationDepartment of Psychiatry, University of Alabama at Birmingham, Birmingham, USA.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, 5032 Great North Road, PO Box 34681, Lusaka, Zambia.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, 5032 Great North Road, PO Box 34681, Lusaka, Zambia. mjv3@uab.edu.
dc.contributor.affiliationSchool of Medicine, University of Zambia, Lusaka, Zambia.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorVinikoor MJ
dc.contributor.authorZyambo Z
dc.contributor.authorMuyoyeta M
dc.contributor.authorChander G
dc.contributor.authorSaag MS
dc.contributor.authorCropsey K
dc.date.accessioned2025-05-23T11:41:36Z
dc.date.issued2018-Jul
dc.description.abstractIn an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification test-consumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDIT-C. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 134 (12.7%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.
dc.identifier.doi10.1007/s10461-018-2030-8
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10517
dc.sourceAIDS and behavior
dc.titlePoint-of-Care Urine Ethyl Glucuronide Testing to Detect Alcohol Use Among HIV-Hepatitis B Virus Coinfected Adults in Zambia.

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