Performance of Xpert
| dc.contributor.affiliation | Centers for Disease Control and Prevention, Atlanta, GA, USA. | |
| dc.contributor.affiliation | Ministry of Health Zambia National TB Programme, Lusaka, Zambia. | |
| dc.contributor.affiliation | Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. | |
| dc.contributor.affiliation | University of Alabama at Birmingham, Birmingham, AL, USA. | |
| dc.contributor.affiliation | CIDRZ | |
| dc.contributor.affiliation | Centre for Infectious Disease Research in Zambia (CIDRZ) | |
| dc.contributor.author | Kasaro MP | |
| dc.contributor.author | Chilyabanyama ON | |
| dc.contributor.author | Shah NS | |
| dc.contributor.author | Muluka B | |
| dc.contributor.author | Kapata N | |
| dc.contributor.author | Krüüner A | |
| dc.contributor.author | Mwaba I | |
| dc.contributor.author | Kaunda K | |
| dc.contributor.author | Coggin WL | |
| dc.contributor.author | Wen XJ | |
| dc.contributor.author | Henostroza G | |
| dc.contributor.author | Reid S | |
| dc.date.accessioned | 2025-05-23T11:41:03Z | |
| dc.date.issued | 2020-Dec-21 | |
| dc.description.abstract | SETTING: Peri-urban health facilities providing HIV and TB care in Zambia. OBJECTIVE: To evaluate 1) the impact of Xpert DESIGN: Quasi-experimental study design with the first cohort evaluated per standard-of-care (SOC; first sputum tested using smear microscopy) and the second cohort per an algorithm using Xpert as initial test (intervention phase; IP). Xpert testing was provided onsite in Chongwe District, while samples were transported 5-10 km in Kafue District. TB was confirmed using mycobacterial culture. RESULTS: Among 1350 PLHIV enrolled, 156 (15.4%) had confirmed TB. Time from TB evaluation to diagnosis ( CONCLUSION: Xpert improved time to diagnosis and treatment initiation, but there was no difference in all-cause mortality. High sensitivity of Determine TB-LAM Ag at lower CD4 count supports increased use in settings providing care to PLHIV, particularly with advanced HIV disease. | |
| dc.identifier.doi | 10.5588/pha.20.0010 | |
| dc.identifier.uri | https://pubs.cidrz.org/handle/123456789/10381 | |
| dc.source | Public health action | |
| dc.title | Performance of Xpert |