Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa.

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dc.contributor.affiliationDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
dc.contributor.affiliationCentre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, Republic of South Africa.
dc.contributor.affiliationDepartment of Cardiology, Helen Joseph Clinic, Johannesburg, Republic of South Africa.
dc.contributor.affiliationDepartment of Pulmonology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland.
dc.contributor.affiliationUniversity Teaching Hospital, Department of Internal Medicine, Lusaka, Zambia.
dc.contributor.affiliationPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
dc.contributor.affiliationInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
dc.contributor.affiliationHealth Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
dc.contributor.authorSamim D
dc.contributor.authorMuula G
dc.contributor.authorBanholzer N
dc.contributor.authorChibomba D
dc.contributor.authorXulu S
dc.contributor.authorBolton C
dc.contributor.authorEvans D
dc.contributor.authorPerrig L
dc.contributor.authorDe Marchi S
dc.contributor.authorGünther G
dc.contributor.authorEgger M
dc.contributor.authorPilgrim T
dc.contributor.authorFenner L
dc.date.accessioned2025-05-23T11:41:12Z
dc.date.issued2025-Jan
dc.description.abstractBACKGROUND: Tuberculosis (TB) is the leading cause of death among people with HIV and a major global health challenge. Subclinical cardiovascular manifestations of TB are poorly documented in high TB and HIV burden countries. OBJECTIVES: The purpose of this study was to quantify the prevalence of cardiovascular involvement in TB patients and investigate changes after completion of anti-TB treatment. METHODS: HIV-positive and HIV-negative patients diagnosed with pulmonary TB between October 2022 and November 2023 were enrolled from 2 tertiary care hospitals in Zambia and South Africa. Standardized transthoracic echocardiography (TTE) was conducted at TB diagnosis and after 6 months of anti-TB treatment. Cross-sectional and longitudinal analyses assessed pericardial effusion, thickening, or calcification, with and without signs of pericardial constriction. RESULTS: A total of 286 TB patients (218 [76%] men, 109 [38%] people with HIV, median age 35 years) underwent TTE at TB diagnosis, of whom 105 participants had a second TTE after completion of treatment. At TB diagnosis, 134 (47%) had pericardial effusions, 86 (30%) thickening, 7 (2%) calcifications, 103 (42%) signs of constriction, and 13 (12%) had definite diagnosis of constriction. After TB treatment, pericardial effusions (47% vs 16%, CONCLUSIONS: Cardiac involvement is frequent in newly diagnosed TB patients. Early pericardial changes may be reversed with anti-TB treatment. Echocardiographic screening facilitates early detection and timely management of cardiovascular involvement in TB patients.
dc.identifier.doi10.1016/j.jacadv.2024.101427
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10425
dc.sourceJACC. Advances
dc.titleCardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa.

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