Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

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dc.contributor.affiliationUniversity of California, San Diego, La Jolla.
dc.contributor.affiliationUniversity of Alabama at Birmingham, Alabama.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka.
dc.contributor.affiliationUniversity of Washington, Seattle.
dc.contributor.affiliationUniversity of Zimbabwe College of Health Sciences, Harare.
dc.contributor.affiliationSeattle Children's Research Institute, Washington.
dc.contributor.affiliationHarvard T. H. Chan School of Public Health, Boston, Massachusetts.
dc.contributor.affiliationNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorHiga N
dc.contributor.authorPelz A
dc.contributor.authorBirch D
dc.contributor.authorBeck IA
dc.contributor.authorSils T
dc.contributor.authorSamson P
dc.contributor.authorBwakura-Dangarembizi M
dc.contributor.authorBolton-Moore C
dc.contributor.authorCapparelli E
dc.contributor.authorChadwick E
dc.contributor.authorFrenkel LM
dc.date.accessioned2025-05-23T11:41:21Z
dc.date.issued2020-Apr-30
dc.description.abstractAmong 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.
dc.identifier.doi10.1093/jpids/piz038
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10459
dc.sourceJournal of the Pediatric Infectious Diseases Society
dc.titleAssociation of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

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