Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.

Simple item page
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka, Zambia Roma.Chilengi@cidrz.org sbd@unc.edu.
dc.contributor.affiliationDepartment of Pediatrics, Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
dc.contributor.affiliationDepartment of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Roma.Chilengi@cidrz.org sbd@unc.edu.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
dc.contributor.affiliationDepartment of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorMwila K
dc.contributor.authorChilengi R
dc.contributor.authorSimuyandi M
dc.contributor.authorPermar SR
dc.contributor.authorBecker-Dreps S
dc.date.accessioned2025-05-23T11:41:49Z
dc.date.issued2017-Jan
dc.description.abstractThe role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
dc.identifier.doi10.1128/CVI.00405-16
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10560
dc.sourceClinical and vaccine immunology : CVI
dc.titleContribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.

Files

Collections

Published