Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings.

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dc.contributor.affiliationFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
dc.contributor.affiliationDepartment of Psychiatry, Harvard Medical School/Massachusetts General Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA.
dc.contributor.affiliationFHI360, Durham, NC, USA.
dc.contributor.affiliationUniversity of Washington, Seattle, WA, USA.
dc.contributor.affiliationResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
dc.contributor.affiliationDepartment of Psychiatry, Harvard Medical School/Massachusetts General Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA. jmagidson@mgh.harvard.edu.
dc.contributor.affiliationNational Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, USA.
dc.contributor.affiliationHarvard Medical School/Beth Israel Deaconess Medical Center, Boston, MA, USA.
dc.contributor.affiliationInstituto de Pesquisa Clinica Evandro Chagas, Rio de Janeiro, Brazil.
dc.contributor.affiliationFred Hutchinson Cancer Research Center, Seattle, WA, USA.
dc.contributor.affiliationJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
dc.contributor.affiliationDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
dc.contributor.affiliationThe Fenway Institute, Fenway Health, Boston, MA, USA.
dc.contributor.affiliationDivision of Infectious Diseases, Departments of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
dc.contributor.affiliationHarvard School of Public Health, Boston, MA, USA.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorMagidson JF
dc.contributor.authorLi X
dc.contributor.authorMimiaga MJ
dc.contributor.authorMoore AT
dc.contributor.authorSrithanaviboonchai K
dc.contributor.authorFriedman RK
dc.contributor.authorLimbada M
dc.contributor.authorHughes JP
dc.contributor.authorCummings V
dc.contributor.authorGaydos CA
dc.contributor.authorElharrar V
dc.contributor.authorCelentano D
dc.contributor.authorMayer KH
dc.contributor.authorSafren SA
dc.date.accessioned2025-05-23T11:42:05Z
dc.date.issued2016-Apr
dc.description.abstractSuccessful biomedical prevention/treatment-as-prevention (TasP) requires identifying individuals at greatest risk for transmitting HIV, including those with antiretroviral therapy (ART) nonadherence and/or 'amplified HIV transmission risk,' defined as condomless sex with HIV-uninfected/unknown-status partners when infectious (i.e., with detectable viremia or STI diagnosis according to Swiss criteria for infectiousness). This study recruited sexually-active, HIV-infected patients in Brazil, Thailand, and Zambia to examine correlates of ART nonadherence and 'amplified HIV transmission risk'. Lower alcohol use (OR = .71, p < .01) and higher health-related quality of life (OR = 1.10, p < .01) were associated with greater odds of ART adherence over and above region. Of those with viral load data available (in Brazil and Thailand only), 40 % met Swiss criteria for infectiousness, and 29 % had 'amplified HIV transmission risk.' MSM had almost three-fold (OR = 2.89, p < .001) increased odds of 'amplified HIV transmission risk' (vs. heterosexual men) over and above region. TasP efforts should consider psychosocial and contextual needs, particularly among MSM with detectable viremia.
dc.identifier.doi10.1007/s10461-015-1142-7
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10612
dc.sourceAIDS and behavior
dc.titleAntiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings.

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