Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study.

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dc.contributor.affiliationDepartment of Medicine, University of Alabama at Birmingham, Birmingham, USA.
dc.contributor.affiliationInstitute of Social and Preventive Medicine, University of Bern, Switzerland.
dc.contributor.affiliationDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
dc.contributor.affiliationTropical Gastroenterology & Nutritional Group, Department of Internal Medicine, University of Zambia, Lusaka, Zambia.
dc.contributor.affiliationDepartment of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
dc.contributor.affiliationBlizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, UK.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorSinkala E
dc.contributor.authorVinikoor M
dc.contributor.authorMiyanda Siyunda A
dc.contributor.authorZyambo K
dc.contributor.authorBesa E
dc.contributor.authorNsokolo B
dc.contributor.authorWandeler G
dc.contributor.authorFoster GR
dc.contributor.authorKelly P
dc.date.accessioned2025-05-23T11:41:08Z
dc.date.issued2020-Jul
dc.description.abstractCirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS. Transient elastography (TE), a measure of liver stiffness can diagnose liver cirrhosis. TE remains unexplored in HSS patients, who generally have normal liver parenchyma. We aimed to explore liver stiffness in HSS. This nested case control study was conducted at the University Teaching Hospital, Lusaka, Zambia between January 2015 and January 2016. We enrolled 48 adults with HSS and 22 healthy controls. We assessed liver stiffness using TE while plasma hyaluronan was used to assess liver fibrosis. Plasma tumor necrosis factor receptor 1 (TNFR1) and soluble cluster of differentiation 14 (sCD14) were used to assess inflammation. The median (interquartile range) liver stiffness was higher in patients, 9.5 kPa (7.8, 12.8) than in controls, 4.7 kPa (4.0, 5.4),
dc.identifier.doi10.1016/j.heliyon.2020.e04534
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10407
dc.sourceHeliyon
dc.titleHepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study.

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