Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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dc.contributor.affiliationDepartment of Pediatrics, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Udayana University, Bali, Indonesia.
dc.contributor.affiliationSchool of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
dc.contributor.affiliationPediatric Department, Cocody University Hospital, Abidjan, Cote d'Ivoire.
dc.contributor.affiliationDepartment of Medicine, Indiana University School of Medicine; Indianapolis, Indiana.
dc.contributor.affiliationDepartment of Pediatrics, BJ Government Medical College and Sassoon General Hospital, Pune, India.
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
dc.contributor.affiliationKalembe Lembe Pediatric Hospital, Kinshasa, Democratic Republic of the Congo.
dc.contributor.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.contributor.affiliationClinical Research Education, Networking and Consultancy (CRENC), Yaoundé, Cameroon.
dc.contributor.affiliationDepartment of Pediatrics, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.
dc.contributor.affiliationCentres GHESKIO, Port-au-Prince, Haiti.
dc.contributor.affiliationDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
dc.contributor.affiliationSolidarMed, Maseru, Lesotho.
dc.contributor.affiliationWorld Health Organization, Geneva, Switzerland.
dc.contributor.affiliationChildren's Hospital 1, Ho Chi Minh City, Vietnam.
dc.contributor.affiliationUniversity of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.
dc.contributor.affiliationDepartment of Paediatrics and Child Health, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa.
dc.contributor.affiliationFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
dc.contributor.affiliationCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
dc.contributor.affiliationDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
dc.contributor.affiliationCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
dc.contributor.affiliationDepartment of Pediatrics, Penang Hospital, Penang, Malaysia.
dc.contributor.affiliationMasaka Regional Referral Hospital, Masaka City, Uganda.
dc.contributor.affiliationTanzanian National Institute of Medical Research, Mwanza, Tanzania.
dc.contributor.authorPatten G
dc.contributor.authorMalateste K
dc.contributor.authorBolton Moore C
dc.contributor.authorSipambo N
dc.contributor.authorMokone L
dc.contributor.authorAnderegg N
dc.contributor.authorWools-Kaloustian K
dc.contributor.authorMichael D
dc.contributor.authorOdhiambo F
dc.contributor.authorKasozi C
dc.contributor.authorDesmonde S
dc.contributor.authorAmorissani-Folquet M
dc.contributor.authorLeroy V
dc.contributor.authorKumara Wati D
dc.contributor.authorNallusamy R
dc.contributor.authorKinikar A
dc.contributor.authorQuy DT
dc.contributor.authorYotebieng M
dc.contributor.authorEbasone PV
dc.contributor.authorLelo P
dc.contributor.authorPinto J
dc.contributor.authorRouzier V
dc.contributor.authorMachado DM
dc.contributor.authorHaw NJ
dc.contributor.authorFord N
dc.date.accessioned2025-05-23T11:42:54Z
dc.date.issued2025-Apr-04
dc.description.abstractEligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
dc.identifier.doi10.1097/INF.0000000000004819
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10746
dc.sourceThe Pediatric infectious disease journal
dc.titleGlobal Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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