Screening for hepatocellular carcinoma among adults with HIV/HBV co-infection in Zambia: a pilot study.

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dc.contributor.affiliationDepartment for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Hepatology, Department of BioMedical Research, University of Bern, Bern, Switzerland.
dc.contributor.affiliationCentre for Infectious Diseases Research in Zambia, Lusaka, Zambia; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.contributor.affiliationCentre for Infectious Diseases Research in Zambia, Lusaka, Zambia.
dc.contributor.affiliationDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: carlotta.riebensahm@insel.ch.
dc.contributor.affiliationDepartment of Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
dc.contributor.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Centre for Infectious Diseases Research, University of Cape Town, Cape Town, Republic of South Africa.
dc.contributor.affiliationCentre for Infectious Diseases Research in Zambia, Lusaka, Zambia; Department of Medicine, University of Alabama, Birmingham, AL, USA.
dc.contributor.affiliationDepartment of Radiology, University Teaching Hospital, Lusaka, Zambia.
dc.contributor.affiliationDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.contributor.affiliationHepatology, Department of BioMedical Research, University of Bern, Bern, Switzerland.
dc.contributor.affiliationDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorRiebensahm C
dc.contributor.authorChitundu H
dc.contributor.authorMuula G
dc.contributor.authorChihota B
dc.contributor.authorSinkala E
dc.contributor.authorSunkutu V
dc.contributor.authorMaurer MH
dc.contributor.authorDufour JF
dc.contributor.authorBerzigotti A
dc.contributor.authorEgger M
dc.contributor.authorBolton-Moore C
dc.contributor.authorVinikoor M
dc.contributor.authorWandeler G
dc.date.accessioned2025-05-23T11:40:52Z
dc.date.issued2022-Mar
dc.description.abstractBACKGROUND AND AIMS: Chronic hepatitis B virus (HBV) infection is the main cause of hepatocellular carcinoma (HCC) in sub-Saharan Africa (SSA). An HCC screening initiative was piloted in an established cohort of individuals co-infected with human immunodeficiency virus (HIV) and HBV on antiretroviral therapy (ART) at two outpatient clinics in Lusaka, Zambia. METHODS: All patients underwent abdominal ultrasound (AUS) and transient elastography. RESULTS: Among 279 patients co-infected with HIV/HBV, 165 (59.1%) were men, median age was 34 years [interquartile range (IQR) 28-39 years] and median CD4 count was 246 cells/µL (IQR 112-355 cells/µL) at ART initiation. While 102 (55.7%) individuals had elevated transaminases, 114 (59.7%) had HBV levels >2000 IU/mL and 59 (24.6%) had significant fibrosis. At their first AUS measurement, 75 (26.9%) participants had hepatomegaly and 69 (24.7%) had periportal fibrosis. Five patients had a liver lesion >1 cm, an indication for confirmatory imaging. CONCLUSIONS: In one of the first HCC screening initiatives in SSA, 2% of patients co-infected with HIV/HBV had significant liver lesions, and one-quarter had findings suggestive of schistosomiasis-induced liver damage.
dc.identifier.doi10.1016/j.ijid.2021.12.338
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/10328
dc.sourceInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
dc.titleScreening for hepatocellular carcinoma among adults with HIV/HBV co-infection in Zambia: a pilot study.

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