Characterization of human respiratory syncytial virus in children with severe acute respiratory infection before and during the COVID-19 pandemic.

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dc.contributor.affiliationUniversity Teaching Hospitals, Pathology and Microbiology Department, Virology Laboratory, Lusaka, Zambia.
dc.contributor.affiliationLevy Mwanawasa Medical University, Institute of Basic and Biomedical Sciences ,Lusaka, Zambia.
dc.contributor.affiliationTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
dc.contributor.affiliationUniversity of Zambia, School of Medicine, Department of Pediatrics and Child Health, Lusaka, Zambia.
dc.contributor.affiliationUniversity of Zambia, School of Veterinary Medicine, Department of Biomedical Sciences, Lusaka, Zambia.
dc.contributor.affiliationCenter for Infectious Disease Research in Zambia, Lusaka, Zambia.
dc.contributor.affiliationCIDRZ
dc.contributor.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.contributor.authorSimusika P
dc.contributor.authorOkamoto M
dc.contributor.authorDapat C
dc.contributor.authorMuleya W
dc.contributor.authorMalisheni M
dc.contributor.authorAzam S
dc.contributor.authorImamura T
dc.contributor.authorSaito M
dc.contributor.authorMwape I
dc.contributor.authorMpabalwani E
dc.contributor.authorMonze M
dc.contributor.authorOshitani H
dc.date.accessioned2025-07-10T11:09:22Z
dc.date.issued2024-Jun
dc.description.abstractOBJECTIVES: Annual outbreaks of human respiratory syncytial virus (HRSV) are caused by newly introduced and locally persistent strains. During the COVID-19 pandemic, global and local circulation of HRSV significantly decreased. This study was conducted to characterize HRSV in 2018-2022 and to analyze the impact of COVID-19 on the evolution of HRSV. DESIGN/METHODS: Combined oropharyngeal and nasopharyngeal swabs were collected from children hospitalized with severe acute respiratory infection at two hospitals in Zambia. The second hypervariable region of the attachment gene G was targeted for phylogenetic analysis. RESULTS: Of 3113 specimens, 504 (16.2%) were positive for HRSV, of which 131 (26.0%) and 66 (13.1%) were identified as HRSVA and HRSVB, respectively. In early 2021, an increase in HRSV was detected, caused by multiple distinct clades of HRSVA and HRSVB. Some were newly introduced, whereas others resulted from local persistence. CONCLUSIONS: This study provides insights into the evolution of HRSV, driven by global and local circulation. The COVID-19 pandemic had a temporal impact on the evolution pattern of HRSV. Understanding the evolution of HRSV is vital for developing strategies for its control.
dc.identifier.doi10.1016/j.ijregi.2024.03.009
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/11444
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/38596821/
dc.sourceIJID regions
dc.titleCharacterization of human respiratory syncytial virus in children with severe acute respiratory infection before and during the COVID-19 pandemic.

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