Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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dc.contributor.authorPatten, Gabriela
dc.contributor.authorMalateste, Karen
dc.contributor.authorBolton-Moore, Carolyn
dc.contributor.authorSipambo, Nosisa
dc.contributor.authorMokone, Limpho
dc.contributor.authorAnderegg, Nanina
dc.contributor.authorWools-Kaloustian, Kara
dc.contributor.authorMichael, Denna
dc.contributor.authorOdhiambo, Francesca
dc.contributor.authorKasozi, Charles
dc.contributor.authorDesmonde, Sophie
dc.contributor.authorAmorissani-Folquet, Madeleine
dc.contributor.authorLeroy, Valériane
dc.contributor.authorKumara, Dewi W.
dc.contributor.authorNallusamy, Revathy
dc.contributor.authorKinikar, Aarti
dc.contributor.authorQuy, Du T.
dc.contributor.authorYotebieng, Marcel
dc.contributor.authorEbasone, Peter V.
dc.contributor.authorLelo, Patricia
dc.contributor.authorPinto, Jorge
dc.contributor.authorRouzier, Vanessa
dc.contributor.authorMachado, Daisy M.
dc.contributor.authorHaw, Nel J.
dc.contributor.authorFord, Nathan
dc.date.accessioned2025-09-17T10:26:26Z
dc.date.issued2025-Apr-04
dc.description.abstractEligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
dc.identifier.doi10.1097/INF.0000000000004819
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/12071
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/40233289/
dc.relation.affiliationFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
dc.relation.affiliationUniversity of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.
dc.relation.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.relation.affiliationDepartment of Paediatrics and Child Health, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa.
dc.relation.affiliationSolidarMed, Maseru, Lesotho.
dc.relation.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.relation.affiliationDepartment of Medicine, Indiana University School of Medicine; Indianapolis, Indiana.
dc.relation.affiliationTanzanian National Institute of Medical Research, Mwanza, Tanzania.
dc.relation.affiliationCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
dc.relation.affiliationMasaka Regional Referral Hospital, Masaka City, Uganda.
dc.relation.affiliationCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
dc.relation.affiliationPediatric Department, Cocody University Hospital, Abidjan, Cote d'Ivoire.
dc.relation.affiliationCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
dc.relation.affiliationDepartment of Pediatrics, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Udayana University, Bali, Indonesia.
dc.relation.affiliationDepartment of Pediatrics, Penang Hospital, Penang, Malaysia.
dc.relation.affiliationDepartment of Pediatrics, BJ Government Medical College and Sassoon General Hospital, Pune, India.
dc.relation.affiliationChildren's Hospital 1, Ho Chi Minh City, Vietnam.
dc.relation.affiliationDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
dc.relation.affiliationClinical Research Education, Networking and Consultancy (CRENC), Yaoundé, Cameroon.
dc.relation.affiliationKalembe Lembe Pediatric Hospital, Kinshasa, Democratic Republic of the Congo.
dc.relation.affiliationSchool of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
dc.relation.affiliationCentres GHESKIO, Port-au-Prince, Haiti.
dc.relation.affiliationDepartment of Pediatrics, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.
dc.relation.affiliationDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
dc.relation.affiliationFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
dc.relation.affiliationWorld Health Organization, Geneva, Switzerland.
dc.sourceThe Pediatric infectious disease journal
dc.titleGlobal Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

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