Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

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dc.contributor.authorHiga N
dc.contributor.authorPelz A
dc.contributor.authorBirch D
dc.contributor.authorBeck IA
dc.contributor.authorSils T
dc.contributor.authorSamson P
dc.contributor.authorBwakura-Dangarembizi M
dc.contributor.authorBolton-Moore C
dc.contributor.authorCapparelli E
dc.contributor.authorChadwick E
dc.contributor.authorFrenkel LM
dc.date.accessioned2025-09-17T10:26:30Z
dc.date.issued2020-Apr-30
dc.description.abstractAmong 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.
dc.identifier.doi10.1093/jpids/piz038
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/12083
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/31194860/
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationHarvard T. H. Chan School of Public Health, Boston, Massachusetts.
dc.relation.affiliationUniversity of Zimbabwe College of Health Sciences, Harare.
dc.relation.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.relation.affiliationUniversity of Alabama at Birmingham, Alabama.
dc.relation.affiliationUniversity of California, San Diego, La Jolla.
dc.relation.affiliationNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
dc.relation.affiliationSeattle Children's Research Institute, Washington.
dc.relation.affiliationUniversity of Washington, Seattle.
dc.sourceJournal of the Pediatric Infectious Diseases Society
dc.titleAssociation of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

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