New Window Into Hepatitis B in Africa: Liver Sampling Combined With Single-Cell Omics Enables Deep and Longitudinal Assessment of Intrahepatic Immunity in Zambia.

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dc.contributor.authorMusonda T
dc.contributor.authorWallace MS
dc.contributor.authorPatel H
dc.contributor.authorMartin OP
dc.contributor.authorOetheimer C
dc.contributor.authorMwakamui S
dc.contributor.authorSinkala E
dc.contributor.authorNsokolo B
dc.contributor.authorKanunga A
dc.contributor.authorLauer G
dc.contributor.authorChung RT
dc.contributor.authorWandeler G
dc.contributor.authorBhattacharya D
dc.contributor.authorKelly P
dc.contributor.authorAlatrakchi N
dc.contributor.authorVinikoor MJ
dc.date.accessioned2025-09-17T10:25:29Z
dc.date.issued2024-Nov-15
dc.description.abstractIn Lusaka, Zambia, we introduced liver fine-needle aspiration biopsy (FNAB) into a research cohort of adults with treatment-naive chronic hepatitis B virus (HBV) infection, with and without human immunodeficiency virus (HIV) coinfection, as well as with acute HBV infection. From 117 enrollment and 47 longitudinal FNABs (at 1-year follow-up), we established participant acceptability and safety. We also demonstrated the quality of the material through single-cell RNA sequencing of selected enrollment FNAs, which revealed a range of immune cells. This approach can drive new insights into HBV immunology, informing cure strategies, and can improve our understanding of HBV natural history in Africa.
dc.identifier.doi10.1093/infdis/jiae054
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/11810
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/38332750/
dc.relation.affiliationTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
dc.relation.affiliationTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
dc.relation.affiliationDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
dc.relation.affiliationDepartment of Medicine, Levy Mwanawasa University Teaching Hospital, Lusaka, Zambia.
dc.relation.affiliationTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
dc.relation.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
dc.relation.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
dc.relation.affiliationDivision of Infectious Diseases, University of California Los Angeles, Los Angeles, California, USA.
dc.relation.affiliationTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
dc.relation.affiliationBlizard Institute, Queen Mary University of London, London, United Kingdom.
dc.relation.affiliationDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
dc.relation.affiliationDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
dc.relation.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.relation.affiliationDivision of Infectious Diseases, University of Alabama Birmingham, Birmingham, Alabama, USA.
dc.sourceThe Journal of infectious diseases
dc.titleNew Window Into Hepatitis B in Africa: Liver Sampling Combined With Single-Cell Omics Enables Deep and Longitudinal Assessment of Intrahepatic Immunity in Zambia.

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