Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings.

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dc.contributor.authorMagidson JF
dc.contributor.authorLi X
dc.contributor.authorMimiaga MJ
dc.contributor.authorMoore AT
dc.contributor.authorSrithanaviboonchai K
dc.contributor.authorFriedman RK
dc.contributor.authorLimbada M
dc.contributor.authorHughes JP
dc.contributor.authorCummings V
dc.contributor.authorGaydos CA
dc.contributor.authorElharrar V
dc.contributor.authorCelentano D
dc.contributor.authorMayer KH
dc.contributor.authorSafren SA
dc.date.accessioned2025-09-17T10:27:21Z
dc.date.issued2016-Apr
dc.description.abstractSuccessful biomedical prevention/treatment-as-prevention (TasP) requires identifying individuals at greatest risk for transmitting HIV, including those with antiretroviral therapy (ART) nonadherence and/or 'amplified HIV transmission risk,' defined as condomless sex with HIV-uninfected/unknown-status partners when infectious (i.e., with detectable viremia or STI diagnosis according to Swiss criteria for infectiousness). This study recruited sexually-active, HIV-infected patients in Brazil, Thailand, and Zambia to examine correlates of ART nonadherence and 'amplified HIV transmission risk'. Lower alcohol use (OR = .71, p < .01) and higher health-related quality of life (OR = 1.10, p < .01) were associated with greater odds of ART adherence over and above region. Of those with viral load data available (in Brazil and Thailand only), 40 % met Swiss criteria for infectiousness, and 29 % had 'amplified HIV transmission risk.' MSM had almost three-fold (OR = 2.89, p < .001) increased odds of 'amplified HIV transmission risk' (vs. heterosexual men) over and above region. TasP efforts should consider psychosocial and contextual needs, particularly among MSM with detectable viremia.
dc.identifier.doi10.1007/s10461-015-1142-7
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/12237
dc.identifier.uri.pubmedhttps://pubmed.ncbi.nlm.nih.gov/26246068/
dc.relation.affiliationDepartment of Psychiatry, Harvard Medical School/Massachusetts General Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA. jmagidson@mgh.harvard.edu.
dc.relation.affiliationFred Hutchinson Cancer Research Center, Seattle, WA, USA.
dc.relation.affiliationDepartment of Psychiatry, Harvard Medical School/Massachusetts General Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA.
dc.relation.affiliationHarvard School of Public Health, Boston, MA, USA.
dc.relation.affiliationThe Fenway Institute, Fenway Health, Boston, MA, USA.
dc.relation.affiliationFHI360, Durham, NC, USA.
dc.relation.affiliationResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
dc.relation.affiliationFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
dc.relation.affiliationInstituto de Pesquisa Clinica Evandro Chagas, Rio de Janeiro, Brazil.
dc.relation.affiliationCentre for Infectious Disease Research in Zambia (CIDRZ)
dc.relation.affiliationFred Hutchinson Cancer Research Center, Seattle, WA, USA.
dc.relation.affiliationUniversity of Washington, Seattle, WA, USA.
dc.relation.affiliationDivision of Infectious Diseases, Departments of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
dc.relation.affiliationDivision of Infectious Diseases, Departments of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
dc.relation.affiliationNational Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, USA.
dc.relation.affiliationJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
dc.relation.affiliationThe Fenway Institute, Fenway Health, Boston, MA, USA.
dc.relation.affiliationHarvard Medical School/Beth Israel Deaconess Medical Center, Boston, MA, USA.
dc.relation.affiliationThe Fenway Institute, Fenway Health, Boston, MA, USA.
dc.relation.affiliationDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
dc.sourceAIDS and behavior
dc.titleAntiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings.

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