Definitive Cefmetazole Therapy for Pediatric ESBL-producing Enterobacterales Bacteremia

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dc.contributor.authorOtsubo Yuto
dc.contributor.authorMurata Yo
dc.contributor.authorKinoshita Kazue
dc.contributor.authorTame Tomoyuki
dc.contributor.authorHorikoshi Yuho
dc.date.accessioned2026-07-24T07:32:48Z
dc.date.issued2026-7-16
dc.description.abstract<jats:sec> <jats:title/> <jats:p>This retrospective study evaluated clinical outcomes of cefmetazole, a cephamycin, compared with carbapenems as definitive therapy for pediatric bacteremia caused by extended-spectrum β-lactamase-producing Enterobacterales. Among 43 patients, outcomes with cefmetazole (n = 17) were comparable to those with meropenem (n = 26), including 30-day mortality and recurrence. Cefmetazole may be a carbapenem-sparing option for pediatric extended-spectrum β-lactamase-producing Enterobacterales bacteremia.</jats:p> </jats:sec>
dc.identifier.doi10.1097/inf.0000000000005326
dc.identifier.urihttps://pubs.cidrz.org/handle/123456789/13259
dc.identifier.uri.pubmedhttps://doi.org/10.1097/inf.0000000000005326
dc.relation.affiliationDivision of Infectious Diseases, Immunology, Department of Pediatrics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationCenter for Pediatric Infectious Diseases, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationDivision of Infectious Diseases, Immunology, Department of Pediatrics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationCenter for Pediatric Infectious Diseases, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationDivision of Molecular Laboratory, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationDivision of Laboratory, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan.
dc.relation.affiliationDivision of Infectious Diseases, Immunology, Department of Pediatrics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.relation.affiliationCenter for Pediatric Infectious Diseases, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
dc.sourcePediatric Infectious Disease Journal
dc.titleDefinitive Cefmetazole Therapy for Pediatric ESBL-producing Enterobacterales Bacteremia

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